Vitamin-B۶ Effect on Decreasing the Risk of Pancreatic Cancer

Introduction: Pancreatic cancer arises when cells in the pancreas begin to multiply out of control and form a mass. This tumor rarely occurs before the age of ۴۰, and more than half of cases of pancreatic adenocarcinoma suffer over ۷۰. Vitamin B۶ is a B group essential vitamin which has been implicated in increasing or decreasing the expression of certain genes. Some of the important effects of vitamin B۶ are transcription of glucocorticoids, gene expression of albumin mRNA, influence on expression of glycoprotein IIb by interacting with various transcription factors. As the result of this vitamin on expression of genes, we decided to review the effect of it on pancreatic cancer. Methods: We conduct a comprehensive search in Medline and PubMed databases for trials, case-control and cohort studies. Results: All the studies confirm that, Consumption of vitamin B۶ in the higher quintiles reduced the risk of pancreatic cancer from ۲۲% to ۵۴% in different studies. The intervention in those taking vitamin B۶ supplement could decrease the advantage of cancer by ۴۲% and consumption with vitamin B۶ + B۹ together could decrease the cancer advantage by ۷۶%. This vitamin may play a role in protecting DNA against oxidative damage and subsequent mutations and therefore can lower the risk of cancer. Conclusions: Vitamin B۶ intake could significantly reduce the risk of pancreatic cancer. The greatest effect of this intervention happen when vitamin B۶ and B۹ consumed together.

کلیدواژه ها:

pancreatic cancer ، vitamin B۶ ، vitamin B۹