The effect of cabazitaxel on learning, balance and anxiety-like behaviors in C۶-induced gliobella stoma rats

Introduction: Glioblastoma is a malignant tumor that originates from the central nervous system and some patients suffer from neurological and psychological disorders. Lack of treatment for glioblastoma is attributed to its drug resistance. The aim of this study was to evaluate the effect of the drug on learning, balance, and anxiety-like behaviors in C۶-induced glioblastoma-induced rats and the role of antioxidant and inflammatory agents. Method: In this study, ۶۳ male Sprague Dali mice (weighing between ۲۰۰ and ۲۵۰ g) were randomly divided into nine groups of seven. Sham group, tumor, TMZ Vehicle, CTZ Vehicle, temozolomide cabazitaxel at doses of ۰.۵mg / kg, ۱mg / kg, ۲mg / kg and ۴mg / kg. All groups received C۶ cells for tumor induction except the sham group. Results: The results of the study showed that all drug treatments reduced tumor volume and CTZ۴ was able to cause the greatest reduction. The survival rate of animals using CTZ۱ was significantly increased compared to other treatment groups. CTZ۱,% OAT, and TMZ,%, increased OAE decreased by tumor, indicating a reduction in anxiety-like behaviors by these drugs. Conclusion: It can be concluded that cabazitaxel at a dose of ۱ mg/kg has beneficial effects on survival rate, neurological cognitive function including decreased anxiety-like activity, increased balance, and memory in the C۶-induced glioblastoma model; However, further studies are needed.

کلیدواژه ها:

cabazitaxel ، learning ، anxiety-like behaviors