Dosimetry Impact of Boron and Its Carriers Structure at Boron Neutron Capture Therapy of a Brain Tumor; A Sim- ulation Study

Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compounds according to the real clinical condition. Moreover, the effect of carrier concentration in tumor volume and boron concentration in carriers' structure would be numerically assessed. Methods: First, a phantom is developed by FLUKAsimulation code to perform dosimetry aspects of Boron and carriers on a typical brain tumor. Moreover, the components of carriers were then simulated separately and the dosimetry parameters were assessed by changing the amount of boron in the carriers’ structure and by the carriers' concentration variations inside and around the tumor to mimic the real condition. Results: The results showed that by increasing boron inside the BPA structure from ۵.۱۷% to ۵۰%, the dose will be increased up to ۷۸.۴۶%. In the BSH, tumor dose is raised to ۹.۰۶% by increasing the amount of boron concentration at carrier structure from ۵۹% to ۸۰%. Moreover, by enhancing the two carriers' concentration inside the tumor volume up to ۳۰%, the dose value is increased up to ۹.۵۹% and ۳.۲۰% for BPA and BSH carriers, respectively. Conclusions: The level of boron in the carrier's structure and also carriers' concentration is highly remarkable on dose delivery inside tumor volume and surrounding tissues.

کلیدواژه ها:

Boron Neutron Capture ، Therapy ، Boron ، Drug Carriers ، Radiation Dosage ، Monte Carlo Method