Study on the potency of domperidone and metoclopramide for spawning induction in Kutum (Rutilus frisii kutum )

The effectiveness of two kinds of dopamine antagonist (DA), metoclopramide (Met) and domperidone (Dom) combined with the gonadotropin releasing hormone analogue (D-Ala۶, Des Gly۱۰ ethylamide) GnRHa was assayed on the ovulation success, latency period, ovulation index (OI) and fertilization success of kutum, Rutilus frisii kutum (Kamenskii, ۱۹۰۱). Brood fish were injected intra-peritoneally as follows: ۲ mg/kg b.w. of carp pituitary extract (CPE) as a control, ۵ g+ ۲.۵mg, ۱mg+ ۵mg and ۲mg+ ۱۰mg/kg b.w. of GnRHa + Met or Dom in a single injection. Based on the ovulation and fertilization success, no significant differences between similar doses of Dom and Met when combined with similar doses of GnRHa were found (p>۰.۰۵). However, in some groups, the OI and latency period were greater when Dom was used as a DA instead of Met (p<۰.۰۵). In general, the results of this study showed that the potency of Dom was nearly same as Met when combined with GnRHa and used as a DA in kutum. It is strongly recommended to repeat the experiment under different conditions to find out definite conclusion.

کلیدواژه ها:

Kutum ، Rutilus frisii kutum ، Spawning ، GnRHa ، metoclopramide ، domperidone