تولید، کنترل کیفی و بررسی توزیع زیست شناختی رادیوداروی Y-EDTMP۹۰ بر روی موش های صحرایی

Pain palliation of bone metastases is one of the perspectives of medical science. Among the different modalities, the use of radionuclides is a well-established approach. One of these radionuclides is Yttrium-۹۰ (۹۰Y) associated with chemical component EDTMP. One method for production of ۹۰Y is neutron activation of ۸۹Y. This radionuclide is a pure beta emitter with a high energy and appropriate half life and has been considered for medical usages in nuclear medicine. In this research ۹۰Y has been produced by irradiation of Y­­­­­۲­­O­­­۳ powder and by the addition of EDTMP ligand, the ۹۰Y-EDTMP complex has been achieved at ambient temperature. Radiochemical purity was investigated by ITLC method and radionuclidic purity by liquid scintillation counting. The radiopharmaceutical biodistributions were performed in different rat organs. 

کلیدواژه ها:

متاستازهای استخوانی ، ایتریم-۹۰ ، EDTMP ، رادیودارو ، توزیع زیست شناختی