Inter action of Potassium ion with Amino Ac idsand the net char ge on the carbonyl of the fr ee bases: A DFT stu dy

سال انتشار: 1391
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 72

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شناسه ملی سند علمی:

ISPTC15_1224

تاریخ نمایه سازی: 11 دی 1400

چکیده مقاله:

The met al ions have importa nt rules in structure and functio n of proteins and other biomolec ules [۱]. Th e rule of m etals as cofactor is greatly magnified in activation of enzym e [۲,۳]. Understanding the mechanism of activation, inhibi tion and oth er reactions, in which t he metal io ns have a critical rule, are achieved by clarifying the interaction of metal ions with protein sequence. Th e alkali metal cations, specially sodium and p otassium are undoubtedly much abundant ions in biologic al systems T he nervous system fun ction serious ly depend o n the activity of the Na +/K+ pump, the transporter responsi ble for mai ntaining stee p Na+ and K + gradients across the neuron plas ma membran e Study of the interacti on between potassium io n and biosystems may be unreach able because of the complexity of t he biomolecules. it seem s that the first estimation of these interactions can be obtained by studying the inte raction of t he metal ions with the simple molecule such as alcohol, amide, am ine and oth er molecules containin g function l group re semble to functional group exist in biomole cules. In this manner, extended research was done to und erstand the n ature of the interaction s [۴,۵]. In this research the interaction of potassium ion with amino acids as building block s of protei ns studied. This research can be considered as starting point in finding the interaction of potassiu m ion intera ction with pr oteins.

کلیدواژه ها:

Potassium Ion ، Potas sium Ion B onded Dimer ، Amino A cids ، Na+/K+ pump

نویسندگان

kh yarjoo

I slamic Azad University,yasooj .Iran

f parvinzadeh

I slamic Azad University,yasooj .Iran