On the chemi cal synth esis and drug delivery response of nap roxen-loa ded PAA/PEG interpolymer com plex-coa ted magne tite nano particles

Recently, Fe۳O۴ magnetic na noparticles is widely used in the field of biolo gy and me dicine due to their adva ntages such as chemica l stability, l ow toxicity and ultra-fine size, etc. Bare magne tite nanoparticles tend to agglomerate due to their large surface area/volume ratio. To preve nt nanoparticle agglomeration a v ariety of po lymeric coatings have been applied to nanoparticles. Pol yacrylic acid (PAA) is well-known for its biocompatibility,and is w idely used in drug delivery system s, especially as a mucoadhesive drug carrier. The high water solubility of PAA limits its u se as a carrier for the sustained re lease of dr ugs. interpolymer complexation of PAA with polyethylen e glycol (P EG) reduce this solubility. interpolymer complexes (IPCs ) between PAA and PEG are formed as a result of hydrogen bonding between the acidic protons of PAA and t he ether oxy gen of PEG . Many drugs have pro blems of po or stability, water insolubility and so on. Good drug carriers play a important r ole in resolving these problems. In this research, we prepared one kind of novel nano-scale carrier for naproxen, usin g Fe۳O۴ na noparticles as core and PAA/PEG IPC as a polymeric shell and napro xen as drug to form napr oxen-loade d magnetic n anoparticles. [۱-۳]

کلیدواژه ها:

Drug delivery ، M agnetite nanoparticles ، Interpolymer complex ، N aproxen