Sy nthesis of ۲-substitu ted benzimidazoles and ۲-aryl-۱H-ben zimidazo les using [Zn( bpdo)۲.۲ H۲O]۲+/M CM-۴۱ na nocatalyst under solvent-free c onditions

Structures contain ing benzimidazole have been well documented to exhibit a wide range of biological properties. This class of molecules has been found for application in s everal therapeutic areas such as antiparasitic [۱], antif ungal, antih ypertensive, antitumor [۲], antimicrobial [۳], anti-inflam matory [۴] and antiviral activities [۵].Accordingly in continuation of our previous works on synthesis of heterogene ous catalys ts and heterocyclic compounds, here we wis h to report the synthe sis and characterizati on of[Zn(b pdo)۲.۲H۲O]+۲/MCM-۴۱ used as catalyst for the synthesis of ۲-substituted benzi midazoles a nd ۲-aryl- ۱H-benzimi dazoles derivatives vi a the simple and efficientcondensation reactions of o -phenylene diamine with carboxylic acids u nder solvent-free condition at ۸۰ ºC .

کلیدواژه ها:

Zinc (II) complex ، MCM-۴۱ ، Benzimidazoles ، O-phenylenediamine ، Carboxy lic acids ، Aldehydes.