E nhancement solubility of poo rly water soluble oxcarbazep ine drug b y nanoporous al umina as a nano carrier

Recently mesoporous materials are wid ely used f or drug delivery syste ms. In this field inorganic nano porous materials are emerging as a ne w category of host/guest systems. Those materials are a fie ld of intensive activity due to thei r high potential in a ver y broad range of applications. The large pours and well- defined structure make mesoporous materials to be used as medical devices, for some inter esting featu res such as their biological stability and drug r elease property. Oxcarbazepine is an anti seizure drug with low solubility and high permeability class ified in cla ss II of BD C [۱-۲]. The aim of the recent work was to propose mesop urous alumina synthesis, an inorga nic nano structure material, as a carrier to improve the di ssolution rate of poorly water-soluble oxcarbaz epine drug, t o enhance the bioavaila bility of poo rly adsorbed drugs, entailing a lowering of therapeutic dos e. Mesoporouse alumina is a good model for some interes ting properties, such as biocompatibility, amphoteric prop erties, very highly pore v olume and wide pore diameter.

کلیدواژه ها:

Meso porous alum ina ، Oxcar bazepine ، Solubility ، Dr ug delivery systems.