Poly terthiop hene Mn( II) is a ne w nano biosensor of bilirubin: A quantum mecha nical approach

Bilirubin is a tetrapyrrole compound that is formed from breakdown of heme in red blood cells, Figure ۱A. The determination of bilirubin, in blood serum samples is considered as a true test of liver f unction. The high concentration of bilirubin is associated with liver diseases, such a s cirrhosis or hepatitis, jaundice, brain damage or even death especially in new borns. Thus, the accurate determination of bilir ubin is clinically important. Various methods have been d eveloped fo r the detection of bilirubin in clinical samples, but most of them suffer from interfe rence from other heme proteins [۱]. The results of recent amperometric study show poly terthio phene Mn( II) (PTTCA Mn۲+) can be used as a nano biosensor of bilirubin [۲], Figure ۱B.

کلیدواژه ها:

Poly terthiophen e Mn(II) ، Na no bio sensor ، Bilirubin ، QM calculations.