Physicochem ical stud y on a new drug na nocarrier made of chitosan a nd h ydroxypropyl-β-cyclodextrin

The p urpose of this work was to design a new type of nanoparticles made of chitosan (CS ) and hydroxypropyl-β-cyclodextrin (HPβCD) and to evaluate their potential for the association and delivery of insulin. The lo gical behi nd the design of thi s new nanosystem was to simultaneously incorporate the Cyclodextrin (CD) drug complexation power and the inh erent prope rties of chit osan nanoparticles, in a unique delivery system . The complexation with the CD allows the solubilization a nd also the protection for sensitive drugs, whereas the loading in the chitosan is ex pected to enhance their absorption. Chitosan na noparticles including H PβCD could be prepared by the ioni c gelation of CS with sodium tripol yphosphate i n the presen ce of CD. T he resultin g nanoparti cles were in the size r ange of ۶۲– ۵۱۴ nm. The association of insuli n led to an increase o f the size of the nanoparticles. The inclusion complex was investigated in solution by phase solubility diagrams and stability constant w as determi ned at differe nt temperatures (۱۰, ۲۵ and ۳۷ ƕC) (pH=۷.۴) to obtain the thermodyna mic parameters of inclusion. The release profil e indicate t hat insulin was very fast released (۸۴–۹۷% i nsulin within ۱۵ min)[۱-۳].

کلیدواژه ها:

Drug nanocarrier ، Chitosan ، Cyclodextri ns ، Physicochemical study