Bioc ompatibility and Antibacter ial Activity of Nanosilver enhanced PLGA Cond uits for P eripheral Nerve Re pair

Periph eral nerve injuries are frequently ca used by tr auma and may lead to a significant loss of sensory or motor functions. The proxi mal end of t he nerve fiber sends out sprouts tow ard the di stal end [۱-۳]. Conduits made of different polym ers have be en develop ed to regenerate a nerv e gap wider than ۱۰ m m [۴, ۵]. Polyester sca ffolds for tissue-engine ering be either manufactured aseptically or sterilized m ust after processing. B iodegradable and suit able mecha nical property of PLG A due to it s excellent b iocompatibility, have been extensiv ely used in tissue engineering [۶]. For it was considered to promote cell proliferation and tis sue healing. Silver n anoparticles exert their antibacterial activity by interacting with the sulfur containing proteins present in bacterial cell membran e as well as with phosphorus contain ing DNA [۷].

کلیدواژه ها:

PLGA ، Biocompatibility ، Antibacterial Activity ، Nanosilver ، Nerve repair.