V oltammetric deter mination of cystea mine using multi wall carb on nanotubes pas te electro de in the presence of ۳,۴-dihydroxy cinnaminc acid as a homogeneous mediato r

Cystea mine is an aminothiol compound used as a drug for the treatment of cystinosi s [۱]. A number of long term clinical trials have shown that cysteamine administration (as cysteamine hydroc hloride) stabilises renal function, delays glo merular deterioration a nd improv es linear growth [۲]. Also, the cysteamine and its disulfide, cystamine, have been shown to be neuropr otective in a number o f cell culture and anim al models [۳]. Numer ous methods have been reported for the determination of CA in harmaceutical and biological samples including chromatography, el ectrophoresis, gas chromatography with flame photometric detection , and electrochemic al methods using modified ele ctrodes. However, Long response ti me, expens ive instru ments, com plicated procedure, and low detectio n capability are the shortcomings associated with most such methods reporte

کلیدواژه ها:

Cysteamine ، Multiwall carbon nanotubes ، Electrocatalysi ، ۳ ، ۴-Dihydroxycinnaminc acid