Stud y of the solvent polarity impacts on the stability of Erythr omycin ethyl s uccinate by means o f hybrid density functional theory based metho d

Erythr omycin is a broad-spectrum antibiotic with activity against gram-po sitive and gram-negative bacteria, and other in fectious age nts, including Chlamydia trachomatis, mycopl asmas (Myco plasma pneumoniae and Ureaplasma urealyticum), and spiroch etes (Treponema pallidum and Bo rrelia spec ies). Erythromycin has good activity againstStreptococcus pneum oniae, S. p yogenes (gr oup A beta-hemolytic streptococci), and Staphy lococcus a ureus. Resistant strains of both streptococci have been encountere d, especiall y in popul ations recently exposed to erythromycin.۱ The incidence of resistance to group A streptococ ci has range d from ۱ to ۱۸% in small studies to up to ۶۰% in a pop ulation that had been w idely treate d with erythromycin for respiratory infections.۱-۳ Most strains of S. au reus are currently sensiti ve to erythromycin. However, the incidence of resistance is increasing . Resistance may develo p to erythro mycin alon e, or may be the result of cross-resistance to other macrolide s.۱ In this w ork, weh ave investig ated the i mpacts of the solvent polarity on the stability of Erythr omycin ethyl succinate by mean s of the B ۳LYP/۳-۲۱G * level of theory with the GAU SSIAN ۰۳ p ackage of programs.۴

کلیدواژه ها:

Erythromycin ethyl succinate ، DFT ، solve nt effect