How the Struc ture of Interferon- Alpha, Responds to Temperature Cha nge? “A Molecular Dynamics Simulation Study”

Interf erons (IFNs) are a group of natural proteins made and released by human cells, in respon se to viral infection and other stimuli. They b elong to the large class of glycoproteins, know n as cytokines, and are named after their ability to interfere with viral replication within host cells. There are three main types of i nterferons, known as: al pha, beta and gamma.Molec ular dynam ics (MD) simulations provide a valuable approach, to the dynamics, struct ure, and stab ility of protein systems. [۱] In this study, we have simulated the interf eron-alpha at four diff rent temperatures (۲۹۸, ۳۱۰, ۳۱۳ and ۳۱۸ K) to investigate the respon se of this protein, to the temperature change. Structural analysis was performe d on the o utput configurations, by analyzing three struct ural parameters. Obtain ed results sh owed the l oss of stability in the tw o limiting temperatures, specially in ۳۱۸K.

کلیدواژه ها:

Protein ، Interferon-Alpha ، Molecular Dynamics Sim ulation