Nanoemulsion and Microemulsion Formulation for the Solubility Enhancement of valsartan

Valsartan drug used orally for the treatment of hypertension, exhibits a low bioavailability (۲۳%), probably related to its poor water solubility. According to the Biopharmaceutical Classification Scheme, Valsartan is a water-insoluble, lipophilic and highly permeable compound. Therefore, it is possible to improve the Valsartan bioavailability by increasing its apparent solubility in water through Nanoemulsion and Microemulsion [۱, ۲]. The aim of this study is to design and develop Nanoemulsion and Microemulsion of Valsartan for enhancing its solubility, hence the oral bioavailability.

کلیدواژه ها:

Nanoemulsion ، Solubility ، Valsartan ، Microemulsion