The relationship between the hematologic indices (PDW, WBC count, MPV) at the admission time and descending ST segment after thrombolysis in patients with myocardial infarction with ST segment elevation hospitalized in Taleghani Hospital of Urmia

Introduction: WBC count and the platelet index (MPV) at the admission time of patients with STEMI, are the strong predictors for undesirable outcomes of patients. The objective of the present study was to determine the relationship between the hematologic indices including MPV and WBC count at the admission time of patients with ST resolution index in patients with STEMI who were treated by thrombolytic agents.Method: In this prospective study, venous blood samples of ۱۱۴ patients with STEMI were taken to determine PDW, MPV and WBC count at patients' referral time and before thrombolytic therapy. According to ST resolution index in ۹۰ minutes after thrombolytic therapy, patients were classified in two groups with ST resolution less than ۵۰% and ST resolution of ۵۰% or more. Finally, values of the laboratory indices above were compared between two ST-resolution groups that this issue was carried out using the SPSS version ۲۱ software.Results: In assessing through ROC curve analysis, it was determined that measuring MPV is not considered as an accurate and effective index in predicting ST resolution after thrombolysis (Area Under Curve: ۰.۵۷۴). WBC count was not an applicable indicator for predicting ST resolution after thrombolysis, as well (Area Under Curve: ۰.۶۶۰). Finally, the results of multiple logistic regression model showed that the only predictor of ST resolution less than ۵۰% is the history of using statins so that history of using statin increased the probability of ST resolution less than ۵۰% for ۷ times (P: ۰.۰۲۸, OR: ۷.۳۰۶).Conclusion: There is not a relationship between the occurrence of complete ST resolution (more than ۵۰%) and the values of both MPV and WBC indices. So, measuring these two indicators may not have the enough validity for predicting ST resolution after thrombolysis. According to our study, patients with history of using statins have a lower prevalence of complete ST resolution (more than ۵۰%).

کلیدواژه ها:

Hematologic indices ، thrombolysis ، myocardial infarction ، ST segment