Simple and efficient synthesis of ۲-styryl-۴H-chromone-۴-one derivatives by modification of the Baker-Venkataraman method

The efficient and facile protocol was developed for the synthesis of ۲-styryl-۴H-chromen-۴-one ۳a-i derivatives. The condensation of substituted ۲-hydroxyacetophenone with cinnamic acid to obtained (E)-۲-acetylphenylcinnamate ۲a-i derivatives, which on treatment with base leads to target ۳a-i derivatives. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. All target compounds are characterized by IR, ۱H NMR, and ۱۳C NMR spectral data.

کلیدواژه ها:

Baker-Venkataraman transformation (BVT) ، Cinnamic acid ، ۲-styryl chromone