Helicobacter pylori in Iran: A systematic review on the antibiotic resistance

Objective(s):Helicobacter pylori (H. pylori) is a pathogenic bacterium that colonizes the stomachs of approximately ۵۰% of the world’s population. Resistance of H. pylori to antibiotics is considered as the main reason for the failure to eradicate this bacterium. The aim of this study was to determine the rate of resistant H. pylori strains to various antimicrobial agents in different areas of Iran.   Materials and Methods: A systematic review of literatures on H. pylori antibiotic resistance in Iran was performed within the time span of ۱۹۹۷ to ۲۰۱۳. Data obtained from various studies were tabulated as following, ۱) year of research and number strains tested, ۲) number of H. pylori positive patients, ۳) study place, ۴) resistance of H. pylori to various antibiotics as percentage, and ۵) methods used for evaluation of antibiotic resistance. Results: Over the period, a total of ۲۱ studies on H. pylori antibiotic resistance have been conducted in different parts of Iran. In these studies, H. pylori resistance to various antibiotics, including metronidazole, clarithromycin, amoxicillin, tetracycline, ciprofloxacin, levofloxacin and furazolidone were ۶۱.۶%, ۲۲.۴% ,۱۶.۰%, ۱۲.۲%, ۲۱.۰%, ۵.۳% and ۲۱.۶%, respectively. We found no study on                 H. pylori resistance to rifabutin in Iran. Conclusion: Compared to the global average, we noted that the prevalence of H. pylori resistance to metronidazole, clarithromycin, amoxicillin, and tetracycline has been rapidly growing in Iran. This study showed that in order to determine an appropriate drug regimen against H. pylori, information on antibiotic susceptibility of the bacterium within different geographical areas of Iran is required.

کلیدواژه ها:

Antibiotic resistance ، Helicobacter pylori ، Iran