The RETN gene rs۱۸۶۲۵۱۳ polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-۴۲۰C/G polymorphism in ۱۸۰ patients with acne vulgaris and ۱۸۰ healthy individuals in a case-control association analysis. In this study, we also investigated the heritability of the RETN susceptible allele from ۱۴۰ trio families with acne affected offspring. The genotyping was performed by polymerase chain reaction and direct DNA sequencing.The RETN-۴۲۰C/G polymorphism was significantly associated with acne in patients compared with healthy controls (P=۰.۰۱۴). The minor allele G at -۴۲۰ was more prevalent in cases vs. controls (P=۰.۰۰۲). The RETN-۴۲۰C/G polymorphism was significantly associated with severity of acne vulgaris in patients (P=۰.۰۰۹۷). The results of a transmission disequilibrium test revealed a significant association between the RETN-۴۲۰C/G polymorphism and acne vulgaris (P<۰.۰۰۱). For the first time in the literature, to our knowledge, we demonstrate a significant association of the RETN-۴۲۰C/G functional polymorphism with familial acne vulgaris.

کلیدواژه ها:

Acne ، Association ، Gene ، Polymorphism ، Resistin