Vitamin D Status in Neonates with Congenital Heart Disease: Its Changes after Heart Surgery and Relationship to the Outcome
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 237
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شناسه ملی سند علمی:
JR_ZUMS-30-13838_005
تاریخ نمایه سازی: 1 آبان 1400
چکیده مقاله:
Original Articles - Clinical medicine (Article Number: e۵۳۷۱۱)
Background and Objective: Vitamin D deficiency has been implicated in a wide range of conditions such as infectious and autoimmune diseases, cardiovascular and cerebrovascular events, and various malignancies to unfavorable birth outcomes. We studied vitamin D status in a group of neonates with congenital heart disease (CHD) and its relationship with the outcome of heart surgery.
Materials and Methods: Total vitamin D levels in plasma were measured before and ۲۴ hours after the operation in ۴۵ neonates with CHD undergoing heart surgery and in ۷۷ hospitalized neonates without a history of CHD as controls, at Children’s Medical Center between March and September ۲۰۱۸.
Results: Preoperative vitamin D levels in patients with CHD were not significantly different from the control group (۴۲.۴ +/- ۱۸.۰ versus ۴۶.۹ +/- ۲۷.۷ nmol/L, P=۰.۶۴۰). Patients’ vitamin D levels decreased postoperatively (۴۲.۴ +/- ۱۸.۰ versus ۳۶.۲ +/- ۱۴.۵ nmol/L, P=۰.۰۱۳). This decline was significant in the cyanotic and open-heart surgery groups, but not in non-cyanotic or closed-heart surgery groups. In ۴۱ (۹۱.۱%) patients, the outcome was successful discharge from the hospital, in ۳ (۶.۷%), the outcome was demise, and in one, it was not determined due to early discharge. Preoperative and postoperative vitamin D levels did not show any relationship with the outcome. However, logistic regression analysis revealed a significant relationship between the amount of postoperative decline in vitamin D levels and the outcome of death (OR=۱.۲۶۱, ۹۵% CI=۱.۰۲۶-۱.۵۵۱, P=۰.۰۲۸).
Conclusion: Results corroborates previous findings and suggests the amount of postoperative decline in vitamin D levels as a predictor of the outcome of heart surgery in CHD.
کلیدواژه ها:
نویسندگان
Ziba Mosayebi
Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Mohamadreza Mirzaaghayan
Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Aliakbar Zeinaloo
Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Behdad Gharib
Dept. of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Pedram Ghahremani
Dept. of Anesthesiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
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