Effect of Amlodipine in Comparison to Nifedipine on Vascular Perfusion Pressure of Isolated Rat Kidney
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 13، شماره: 1
سال انتشار: 1389
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 163
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شناسه ملی سند علمی:
JR_IJBMS-13-1_006
تاریخ نمایه سازی: 30 مهر 1400
چکیده مقاله:
Objective(s) This study aimed to investigate and to compare the effects of nifedipine and amlodipine, dihydropyridine (DHP) calcium channel blockers (CCBs) on perfusion pressure of isolated perfused rat kidney. Materials and Methods Following the establishment of renal perfusion with a constant baseline pressure of ۸۵-۹۵ mmHg, the renal vasculature was constricted by phenylephrine (PE) injection. Changes in the baseline perfusion pressure were recorded. Then nifedipine and amlodipine prepared in perfusion medium was fed to the kidney for ۳۰ min. Finally alterations in the baseline pressure arising from PE administrations in the presence of CCBs were recorded and data analyses were done. Results PE-induced increases in perfusion pressure attenuated significantly in the presence of ۵ and ۱۰ pM of nifedipine and ۱, ۵, and ۱۰ pM of amlodipine. Increases in perfusion pressure arising from PE (۱۰۰ and ۲۰۰ pM) in the presence of amlodipine (۱, ۵, and ۱۰ pM) was significantly less than that in the presence of nifedipine (۱, ۵, and ۱۰ pM). Calculated EC۵۰ value of amlodipine for inhibition was significantly lower than that of nifedipine. Based on the EC۵۰ values, the potency of amlodipine in inhibiting PE-induced responses is significantly higher compared to nifedipine. Conclusion The potency of amlodipine in inhibiting PE-induced increments in renal perfusion pressure is significantly higher compared to nifedipine.
کلیدواژه ها:
نویسندگان
Lili Sepehr-Ara
Department of Biology, Kazeroon Branch, Islamic Azad University, Kazeroon, Iran
Soltan Ahmed Ebrahimi
Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
Vahab Babapoor
Department of Physiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
Massoud Mahmoudian
Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
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