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مقالات فارسیISIکنفرانسهاژورنالها

Significant roles played by interleukin-۱۰ in outcome of pregnancy

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 2
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 296

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295974

شناسه ملی سند علمی:

JR_IJBMS-19-2_001

تاریخ نمایه سازی: 30 مهر 1400

چکیده مقاله:

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-۱۰(IL-۱۰) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-۱۰ during pregnancy may result in several pathologic conditions such as preterm labor. IL-۱۰ leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK۱/STAT۳ pathway in the target cells. This review has collected recent data regarding the status of IL-۱۰ expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.

کلیدواژه ها:

IL-۱۰ ، Preterm delivery ، Term delivery

نویسندگان

Masoud Mobini

Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Maryam Mortazavi

Department of Gynecology and Obstetrics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Somayeh Nadi

Yadegar Emam Health Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Zare-Bidaki

Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Somayeh Pourtalebi

Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Kazemi Arababadi

Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

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