The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats

Objective(s): Particularly in developing countries, selenium and/or iodine deficiencies are encountered and use of pesticides in agriculture are not well-controlled. Fenvalerate is a pyrethroid insectide used in agriculture and has applications against a wide range of pests. This study was designed to evaluate the effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzyme activities in the presence of iodine and/or selenium deficiency on a rat model. Materials and Methods: Iodine and/or selenium deficiency was induced by feeding  three-week-old Wistar rats with a diet containing <۰.۰۰۵ mg selenium kg-۱, and/or administering ۱% sodium perchlorate in drinking water for ۷ weeks. Test groups received fenvalerate (۱۰۰ mg kg-۱ BW IP) for the last ۷ days. Hepatic and cerebral microsomal aniline hydroxylase (CYP۲E۱) and cytosolic glutathione S-transferase (GST) activities were determined. Besides, hepatic NADPH-cytochrome P۴۵۰ reductase (P۴۵۰R), ethoxyresorufin O-deethylase (EROD, CYP۱A۱/۱A۲) and penthoxyresorufin O-depenthylase (PROD, CYP۲B۱/۲B۲), activities were also measured. Results: Fenvalerate had a general inductive effect on the hepatic and cerebral xenobiotic metabolizing enzyme activities. Moreover, enzyme activities were also altered by iodine and/or selenium deficiency, but the effects seemed to be enzyme- and tissue-specific. Conclusion: The inductive effect of fenvalerate, particularly in high dose exposures, may change the metabolism of several xenobiotics, including drugs, as well as endogenous substrates. The effects may vary depending on the selenium and/or iodine status of individual.

کلیدواژه ها:

Fenvalerate ، Iodine ، Selenium ، Thyroid hormones ، Xenobiotic metabolizing - enzymes