Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 6
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 226
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شناسه ملی سند علمی:
JR_IJBMS-20-6_013
تاریخ نمایه سازی: 28 مهر 1400
چکیده مقاله:
Objective(s): The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for ۳ doses) and sub-acute (for ۱۴ days) to mice. Materials and Methods: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (۰.۵, ۱, and ۲ mg/kg). In a sub-acute study (۱۴ days in ۲۴-hr intervals) antidepressant-like effects of essential oil (۰.۵, ۱, and ۲ mg/kg) with the same route were assessed in FST and tail suspension test (TST). Anti-anxiety and motor activities were evaluated using elevated plus-maze (EPM) and open field tests, respectively. Determination of different constituents within the sample oil was via gas chromatography–mass spectrometry (GC–MS) analysis. Results: Repetitive administration of cinnamon essential oil (۰.۵, ۱, ۲ mg/kg) during ۱۴ days significantly decreased the time of immobility in both FST and TST as compared to the control group. Mice treated with oil at the dose of ۲ mg/kg spent a longer time and had more entries into the open arms of EPM as compared with the vehicle-treated ones. According to GC-MS analysis, ۴۶ chemical compounds were identified in the studied cinnamon essential oil with the main constituent being trans-cinnamaldehyde (۸۷.۳۲%). Conclusion: Cinnamon essential oil might be used as an adjunctive therapy in improving symptoms of depressive and anxiety disorders. However, dose-response effects need further evaluation. Trans-cinnamaldehyde might be responsible for the beneficial effect observed.
کلیدواژه ها:
نویسندگان
Reyhaneh Sohrabi
Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Nasim Pazgoohan
Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Hasan Rezaei Seresht
Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
Bahareh Amin
Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
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