The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD۶۵ and GAD۶۷ genes in hippocampus of newborn and adult male rats

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63

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شناسه ملی سند علمی:

JR_IJBMS-20-9_005

تاریخ نمایه سازی: 28 مهر 1400

چکیده مقاله:

Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was administrated to newborn rats and their GAD۶۵ and GAD۶۷ expression in hippocampus was evaluated before and after puberty. Materials and Methods: Newborn male Wistar rats were received sodium thiopental (۳۵ mg/kg) daily for ۱۱ days (from ۴ to ۱۴ days after birth). Expression of GAD۶۵ and GAD۶۷ in their hippocampus was compared with control groups in ۱۵ and ۴۵ days after birth with RT-qPCR method. Results: Significant down regulation of GAD۶۵ and GAD۶۷ gene expression was observed in treated rats compared with control group in ۴۵ days after birth animals. But no significant difference was shown between experimental and control groups ۱۵ days after birth animals. Conclusion: The effect of sodium thiopental on GAD۶۵ and GAD۶۷ expression only at adult rats showed a latent period of influence which can be attributed to dosage or intension of sodium thiopental neurotoxicity. Significant down regulation of GAD۶۵ and GAD۶۷ showed unwanted effect of sodium thiopental as GABA mimetic drug in critical period of development.

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نویسندگان

Masoud Naseri

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Abbas Parham

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Ali Moghimi

Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

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