The role of TSG-۶ and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 149

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شناسه ملی سند علمی:

JR_IJBMS-20-11_010

تاریخ نمایه سازی: 28 مهر 1400

چکیده مقاله:

Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene ۶ (TSG-۶) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC.   Materials and Methods: Expression of TSG-۶ and uroplakin III was determined by immuno- histochemistry of bladder biopsy samples from control human subjects and patients with verified BPS/IC. Our rat model of BPS/IC was employed to measure the perfusion of bladders with hyaluronidase, and assessment of the effect of TSG-۶ administration on disease progression. Treatment effects were assessed by measurement of metabolic characteristics, RT-PCR of TGR-۶ and interleukin-۶, bladder histomorphology, and immunohistochemistry of TGR-۶ and uroplakin III. Results: The bladders of patients with BPS/IC had lower expression of uroplakin III and higher expression of TSG-۶ than controls. Rats treated with hyaluronidase for ۱ week developed the typical signs and symptoms of BPS/IC, and rats treated with hyaluronidase for ۴ weeks had more serious disease. Administration of TSG-۶ reversed the effects of hyaluronidase and protected against disease progression. Conclusion:Our results indicate that TSG-۶ plays an important role in maintaining the integrity of the bladder epithelial barrier.

کلیدواژه ها:

Bladder pain syndrome/interstitial cystitis ، Immunofluorescence staining ، Interleukin-۶ ، TSG-۶ ، Uroplakin III

نویسندگان

Yi-Song Lv

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Rui Gao

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Qing-Ming Lin

Department of Emergency Medicine, Fujian Provincial Hospital, Fuzhou ۳۵۰۰۰۵, China

Tao Jiang

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Qin Chen

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Song-Xi Tang

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Hou-Ping Mao

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Hui-Liang Zhou

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

Lin-Sheng Cao

Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou ۳۵۰۰۰۵, China

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