Effects of troxerutin on anxiety- and depressive-like behaviors induced by chronic mild stress in adult male rats
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 8
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 166
فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-21-8_002
تاریخ نمایه سازی: 27 مهر 1400
چکیده مقاله:
Objective(s):Chronic stress has been linked to the pathophysiology of mood disorders including anxiety and depression. In this study, we aimed to investigate the effect of troxerutin (TRX), as a flavonol, on stress-induced anxiety and depression.Materials and Methods: ۵۶ animals were randomly divided into seven groups (n=۸ per group) as follows: control, saline, TRX ۵۰, TRX ۱۵۰, TRX ۳۰۰, Diazepam, and Imipramine. Chronic mild stress (CMS) was induced by restraining animals in Plexiglas cylinders for ۱ hr each day for ۲۵ consecutive days. Different doses (۵۰, ۱۵۰, and ۳۰۰ mg/kg, oral gavage) of troxerutin was gavaged for ۱۴ consecutive days. At the end of treatments, anxiety- and depressive-like behaviors were tested using elevated plus-maze (EPM), open field test (OFT), and forced swimming test (FST). Results: CMS significantly increased immobility (P<۰.۰۵) and decreased swimming (P<۰.۰۱) time in FST. However, different doses of troxerutin significantly decreased immobility (P<۰.۰۱) and increased swimming (P<۰.۰۰۱) time. CMS also significantly (P<۰.۰۱) decreased the percentage of open arm entrance (%OAE), whereas troxerutin significantly increased both %OAE and percentage of open arm time (%OAT) in the EPM. Moreover, CMS significantly decreased time spent in the center (P<۰.۰۰۱) and the number of center entrances (P<۰.۰۱) in the OFT. However, troxerutin significantly increased time spent in the center and number of the entrances crossing. Furthermore, CMS significantly increased serum cortisol levels and troxerutin decreased it.Conclusion: Troxerutin demonstrated anxiolytic- and antidepressant-like activities in rodents, which supports the use of herbal medicine in the mood disorders.
کلیدواژه ها:
نویسندگان
Maryam Azarfarin
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Fereshteh Farajdokht
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
Shirin Babri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Farzad Salehpour
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
Milad Taghizadeh
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
Gisou Mohaddes
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :