The role of nutrition in multiple sclerosis

Background and Aim : The role of nutritional interventions with a significant effect on the prognosis of multiple sclerosis (MS), especially in the relapsing-remitting type, if used at the beginning of the disease and with minimal disability has been discussed. Methods : While reviewing in scientific databases (Pub Med, Google Scholar, Science Direct) by applying keywords and also applying free full text filter in the period ۲۰۱۷ onwards, ۵۷ approved articles in these databases and completely related to the topic ahead of us were obtained. Results : Required diet includes reducing fat intake, getting enough essential omega-۶ and omega-۳ fatty acids, antioxidants, vitamins D and ۱۲B and increasing consumption of foods containing fiber, biotin with carboxylase dependent function In the tricarboxylic acid (TCA) cycle, while increasing the expression of the ATP molecule, it is contrary to the hypoxic consequences of MS and also curcumin reduces nerve damage and inflammation by reducing inflammatory mediators such as IL-۱? and TNF-? and is effective in mitochondrial dynamics. And causes oxidative damage by creating aerobic metabolism. Conclusion : These are promising topics to study in the management of MS. However, these patients are at risk of malnutrition with anorexia due to inactivity and side effects of medications. But, a strategic nutritional model has not yet been developed for patients to take these supplements. Therefore, more clinical trials are needed to fully evaluate its effect on the recovery of MS.

کلیدواژه ها:

Multiple sclerosis ، Nutrition ، Diet.