Gut dysbiosis is associated to multiple sclerosis

Background and Aim : Intestinal microbiota perturbation has been significantly related to several human disorders, including rheumatoid arthritis, obesity, diabetes, and multiple sclerosis (MS). Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disorder driven by the aberrant infiltration of immune cells into the central nervous system (CNS). MS pathogenesis has been resulting from the interplay of genetic predisposition and environmental factor, although the exact role of environmental factors in the pathophysiology of MS remains unknown. The aim of this study Assessment of the role of gut microbiota in multiple sclerosis pathogenesis.Methods : This study examines the relationship between multiple sclerosis and gut microbiota, using the relevant published articles about microbiota and multiple sclerosis searched in PubMed and Google Scholar databases from ۲۰۰۸ to ۲۰۲۱.Results : Recent research on gut dysbiosis (alteration of commensal bacteria composition) conducted in MS patients and experimental autoimmune encephalomyelitis (EAE), its murine model of encephalitis, has shown that commensal microbiota may play a serious role in the pathogenesis of MS. The gut microbiota regulates the host immune and nervous systems and could have impact role in multiple sclerosis.Conclusion : Given the increase in the prevalence of MS worldwide understanding the interaction in the gut-immune-brain axis relates to the influence of microorganisms in the development of MS and modification of the intestinal microbiome could be a future promising treatment in MS. In this review, the characteristics of gut microbiota, the association between gut microbiota and MS, various factors influenced on intestinal microbiota modification have been discussed.

کلیدواژه ها:

Microbiota ، Multiple sclerosis ، CNS autoimmunity ، dysbiosis