DRUG MICROBIOM INTRACTION –A Short Review

Background and Aim : The human microbiome plays an important role in controlling vital hemostatic mechanisms in the body. It is known as a major mediator of pharmacological activity. Microbiota chemistry produces drugs and toxicity, intestinal bacteria produce a wide range of enzymes and metabolites that may alter chemicals. The intestinal microbiome can be an active, inactive, or toxic drug. This can directly affect drug metabolism through biotechnology, which converts organic compounds into other chemical forms or metabolites and is done by microorganisms. The most common mechanisms of intestinal microbiota metabolism are hydrolytic and reactive reactions. In addition, many other chemical reactions such as acetate, demineralization, dehydroxylation, decarboxylation, methylation, solution decomposition, and proteolysis have been reported. In addition to environmental drugs, the microbiota can indirectly control the effect of the drug by altering the host metabolism and producing metabolites that compete with the drug-receptor. This study examines the effects of drugs on people with different microbes. Here we review recent studies for better investigation, based on the mechanism of drug-microbiome interaction and their response. Methods : search and study in databases and papers Results : As discussed in this short review, a large number of drugs already in the market are substrates for microbial metabolism, and this highlights the importance of including the microbial metabolism of the drug during the development phase. most of the drugs changed with microbiome metabolic. it may become better or worse or toxicity for our body Conclusion : An understanding of the implications of microbial metabolism is expected to increase with time as more and more drugs are being identified as substrates for gut Microflora. As discussed in this short review, a large number of drugs already in the market are substrates for microbial metabolism, and this highlights the importance of including the microbial metabolism of the drug during the development phase. most of the drugs changed with microbiome metabolic. it may become better or worse or toxicity for our body

کلیدواژه ها:

Drugs ، microbials ، microbiota ، bacteria ، grazing ، drug More about this source textSource text required for additional translation information