In Vitro Susceptibility of clinical Rhodotorula mucilaginosa isolates from animal source to antifungal agents

Background and Aim : Rhodotorula species are common non-virulent environmental yeasts and emerged as opportunistic pathogens, causing catheter associated fungemia among immunocompromised hosts. Rhodotorula mucilaginosa is considered the most common species involved in human and animal infections. The aim of the present study was to evaluate antifungal susceptibility patterns of Rh. mucilaginosa strains isolated from animal. Methods : The ۳۷ isolates of Rh. mucilaginosa obtained from Chicken (۷ isolates), cat (۱۲ isolates), Horse (۵ isolates), Canary (۷ isolates) and Camel (۶ isolates) were tested for susceptibility to standard antifungal drugs.Results : The Geometric Mean of minimum inhibitory concentration (MIC) values of Amphotericin B, ۵-Fluorocytosine and Caspofungin were ۱.۱۰ µg/ml (Range; ۰.۱۲۵-۳۲), ۰.۲۰ µg/ml (Range; ۰.۰۶-۱) and ۵.۸۲ µg/ml (Range; ۲-۳۲), respectively. These values of Fluconazole, Itraconazole, Voriconazole and Posaconazole calculated ranged from ۰.۱۲۵-۳۲ µg/ml. Comparing the MIC۹۰ for all Rh. mucilaginosa strains, the lower MIC۹۰ were observed for ۵-Fluorocytosine (۰.۲ µg/ml) and Posaconazole (۰.۴۹ µg/ml). Conclusion : Rhodotorula's infections are usually resistant to treatment with antifungal drugs especially triazoles and echinocandins.Our results indicated that Fluconazole does not effective against the Rh. Mucilaginosa isolates from animal source. Furthermore, ۵-Fluorocytosine and Posaconazole is the best drug against this genus in comparison to other azole drugs.

کلیدواژه ها:

Rhodotorula mucilaginosa ، ۵-Fluorocytosine amphotericin B ، itraconazole ، voriconazole ، antifungal susceptibility