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Investigation of gastrointestinal Escherichia coli phylogenetic linage in immunocompromised pediatrics

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 132
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شناسه ملی سند علمی:

MEDISM22_019

تاریخ نمایه سازی: 8 مهر 1400

چکیده مقاله Investigation of gastrointestinal Escherichia coli phylogenetic linage in immunocompromised pediatrics

Background and Aim : Multiple stays in hospital considered as a risk factor for hospital acquired infection (HAI), especially in immunocompromised pediatrics. Dysbiosis of the fecal microbiota could occur in these children with bacteria originating from the hospital environment. To show this relationship, phylogenetic homology of Escherichia coli isolates among admitted pediatrics to the bone marrow transplantation and oncology wards was investigated in a hospital in Tehran, Iran. Methods : A total of 56 immunocompromised children were included in this investigation. Culture of fecal samples and characterization of E. coli isolates was done according to standard methods. ERIC-PCR genotyping method was used to identify the phylogenetic relationship and clonal diversity of the strains.Results : Out of 31 E. coli isolates, homology of ERIC-PCR patterns was detected between 21 pairs of them. The isolates with identical patterns were related to hospitalized patients in the oncology (25.8%, 8/31), transplantation (9.6%, 3 /31), or oncology/transplantation wards (22%, 7/31), respectively. We detected 21 different clones of E.coli with considering 100% of homology in both wards. Nearly 100%, 90%, 75% homology in ERIC-PCR patterns was detected in 41.9%, 54.8%, and 25% of the E. coli strains with identical, similar, and related clones, respectively. Conclusion : Homology of the E. coli isolates among immunocompromised children at different wards of the hospital was shown in this study. Control programs are necessary to avoid transmission of resistant clones of pathogenic bacteria between different hospital wards and from the hospital environment to the community.

کلیدواژه های Investigation of gastrointestinal Escherichia coli phylogenetic linage in immunocompromised pediatrics:

نویسندگان مقاله Investigation of gastrointestinal Escherichia coli phylogenetic linage in immunocompromised pediatrics

Nasim Almasian Tehrani

Department of microbiology and microbial biotechnology, faculty of life sciences and biotechnology, Shahid Beheshti University, Tehran, Iran

Neda Soleimani

Department of microbiology and microbial biotechnology, faculty of life sciences and biotechnology, Shahid Beheshti University, Tehran, Iran

Shahnaz Armin

Pediatric Infections Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Leila Azimi

Pediatric Infections Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Masoud Alebouyeh

Pediatric Infections Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Bibishahin Shamsian

Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran