Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 250

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شناسه ملی سند علمی:

JR_IJBMS-21-12_017

تاریخ نمایه سازی: 27 شهریور 1400

چکیده مقاله:

Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on methamphetamine-induced memory impairment in rats. Materials and Methods: Male Wistar rats received methamphetamine (۱۰ mg/kg, intraperitoneally) for ۷ days. Thirty minutes before each injection, animals were given cinnamaldehyde (۲۰, ۴۰, or ۸۰ mg/kg) or rivastigmine (۱ mg/kg). The spatial learning and memory were examined using the Morris water maze test. The expression of extracellular signal-regulated kinase (ERK) phosphorylation in the frontal cortex and hippocampus was also detected by immunohistochemical method.Results: Administration of methamphetamine increased the latency to find the platform in the learning phase, while administration of cinnamaldehyde (۴۰ mg/kg) or rivastigmine before methamphetamine reversed the increased latency. Administration of cinnamaldehyde, at the dose of ۴۰ mg/kg with methamphetamine, increased the time and distance traveled in the target quadrant in comparison with the amphetamine group. Moreover, the methamphetamine and cinnamaldehyde-treated group had higher expression of phosphorylated ERK۱/۲ in the prefrontal cortex in comparison with the methamphetamine-treated animals.Conclusion: The present data demonstrated that repeated METH administration impaired cognitive performance through the ERK pathway and decreased the phosphorylation of ERK۱/۲ in the prefrontal cortex while administration of cinnamaldehyde restored both effects. Accordingly, cinnamaldehyde may be a valuable therapeutic tool for the treatment of cognitive deficits associated with methamphetamine consumption.

نویسندگان

Mohammad Saeed

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Ameneh Ghadiri

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

Farzin Hadizadeh

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Armin Attaranzadeh

Milad Infertility Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Mohaddeseh Sadat Alavi

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Leila Etemad

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

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