Study of the anti-cancer effects of Grandivittin on A۵۴۹ lung cancer cell line

Lung cancer is one of the most common cancers and the leading cause of cancer death. It is estimated that there are approximately ۱.۵ million deaths from lung cancer worldwide each year. Therefore, identifying new diagnostic markers and treatment goals for lung cancer is very important. Because common drugs cause cell resistance and have many side effects. Therefore, finding a plant-based agent to control cancer can be very promising. In this study, we investigated the toxicity of coumarin derivatives (Grandivittin) extracted from the native plant of Iran through MTT, flow cytometry methods, and its effect on the expression of apoptotic pathway genes through Real-time PCR on A۵۴۹ cell line. We have observed that this substance at a concentration of ۰.۷ mM has a toxic effect and can induce apoptosis in treated cancer cells.

کلیدواژه ها:

cell line treatment ، coumarin ، gene expression ، apoptosis ، IC۵۰