The effect of calcium nanofluoride on breast cancer cell MDA-MB-۲۳۱ migration

Cancer is abnormal cell proliferation. When cancer cells develop in the breast tissue, it is called breast cancer. Nanotechnology began at the suggestion of renowned physicist Richard Feynman. Nanotechnology has many advantages over conventional methods of cancer diagnosis, treatment and prevention. In this study, MDA-MB-۲۳۱ cancer cell migration was prevented by using calcium nanofluoride. Calcium nanofluoride was formed from the combination of calcium carbonate with synthesized hydrogen fluoride by sonication as nanoparticles. Verification of fabricated nanoparticles was performed using (TEM) and (DLS). Breast cancer cells were cultured in DMEM medium and by MTT assay on MDA-MB-۲۳۱ cell lines, cell viability was assessed and LC۵۰ calcium nanofluoride was obtained. Then, according to the obtained LC۵۰, cell migration test was performed on breast cancer cells. Finally, it was found that calcium nanofluoride reduced the migration of cancer cells by ۳۰%. Calcium fluoride nanoparticles have anti-cancer properties. More research is needed to confirm it as an anti-cancer agent.

کلیدواژه ها:

Lymph nodes ، Richard Feynman ، MTT test ، cell death ، LC۵۰