Studing the short tem memory of male offspring of intact rats treated with sulpiride

Studies have shown that memory is impaired after using the D۲ (D۲R) dopamine receptor antagonists.as well as, there are dopamine receptors in the reproductive system. Probably, using the inhibitors of D۲ receptors by affecting the reproductive system influences the physiological processes of the offspring of the parents under treatment. The aim of this study was to investigate the effect of dopamine D۲ receptors (D۲R) inhibition on the short term memory of offspring from male rats treated with sulpiride.Twenty adult male Wistar rats weighing ۱۹۰± ۱۰ g were divided into two groups including saline and sulpiride (antagonist of D۲ dopamine receptors) (۴ mg/kg bw, ip) received. After ۱۴ days treatment, each male rat mated with three adult female rats; male offspring of these rats were raised to normal under puberty, and after puberty, they were evaluated for Short term memory by cross-maze.The results of the cross maze showed that actual alternation percentage as a memory evaluation index, was significantly reduced in offspring of male rat under treatment with sulpiride compared with saline control group (p<۰.۰۵).Inhibition of dopamine D۲ receptors in male parent reduces the Short term memory of male offspring.

کلیدواژه ها:

Memory ، Sulpiride ، dopamine ، Offspring