The study of rs۴۵۰۸۱۹ polymorphism on metabolic syndrome in people with mutation in DYRK۱B gene

Metabolic syndrome is the clustering of multiple factors that directly increases the risk of cardiovascular disease and type ۲ diabetes. Two missense mutations of the DYRK۱ B gene, including H۹۰P and R۱۰۲C, were recently found to co-segregate with a rare autosomal-dominant form of the metabolic syndrome, called abdominal obesity-metabolic syndrome)AOMS۳(. Affected individuals developed an early-onset cardiovascular disease, hypertension, central obesity, and diabetes. DYRK۱B R۱۰۲C mutation significantly increases the key gluconeogenic enzyme and glucose-۶-phosphatase. In this research, we evaluated the association between SNP rs۴۵۰۸۱۹۴ and metabolic syndrome in individuals with DYRK۱B gene mutation.SNP rs۴۵۰۸۱۹ genotypes are determined by polymerase chain reaction in۱۲۱ heterozygote and homozygote subjects in DYRK۱B gene. PCR products were sequenced and then a survey was done on sequences. Data were analyzed with chi-square statistical testing and Prism۶ and SPSS software.results do not showed a correlation between this SNP alleles and increase metabolic syndrome risk in individuals suffering from metabolic syndrome and this illness risk factors

کلیدواژه ها:

Metabolic syndrome ، Cardiovascular disease ، DYRK۱B gene ، SNP rs۴۵۰۸۱۹