Effect of alamandine on cardiac contractility, blood pressure and ECG of rats treated with cardiotoxic agent doxorubicin

The renin-angiotensin system (RAS) plays an important role in the pathogenesis of cardiovascular diseases. Alamandine is recently identified as a component of RAS. In the cardiovascular system, alamandine actions included vasodilation, antihypertensive, and antifibrosis effects. The aim of the present study was to evaluate the potential protective effect of alamandine on doxorubicin (Dox)-induced cardiac toxicity. Rats received DOX (۳.۷۵ mg / kg/week) i.p to reach total cumulative dose (۱۵ mg / kg) and alamandine (۵۰ μg / kg / day) via mini-osmotic pumps for ۴۲ days. Cardiac toxicity was evaluated by measuring hemodynamic parameters, electrocardiogram and histopathological findings. The results indicated that systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), +/- dP/dt(max) in rats treated with DOX were significantly lower and left ventricular end diastolic pressure (LVEDP) was significantly higher than control and DOX+alamandine group. Doxorubicin increased PR and QT intervals significantly. Whereas, RR intervals were significantly decreased. Alamandine co-administration significantly attenuate these changes. The histopathological findings confirm the results. In conclusion, alamandine attenuated doxorubicin-induced alteration in ECG pattern and restored the mechanical and physiological functions of the heart

کلیدواژه ها:

Renin Angiotensin System ، Heart