Why does the world need an integrative system approach to biology

It is now ۲۰ years since the first human genome sequence was announced in ۲۰۰۱. The expectation was that, by now, we would have cures for cancer, heart disease, and for most of the major diseases of the organs and systems. We have made incremental progress, but nothing like the major change that was predicted. WHY? We got genetic causation the wrong way round, Genes are used by organisms, not the reverse. The organism activates, controls, and modifies its genome. What is the evidence and what are the implications for Biology in the ۲۱st century? Those are the topics of this Lecture. I will then address the question of sustainable development.