Investigation of correlation of the Helicobacter pylori infection prevalence with serum ferritin and iron levels

Background and Aim : Helicobacter pylori is one of the most common bacteria responsible for chronic infection in human. This bacteria causes a wide range of gastrointestinal diseases, including chronic gastritis, peptic ulcer and gastric adenocarcinoma. Due to the decrease in gastric acid secretion in this condition, some studies have pointed to the effect of Helicobacter pylori outbreak on iron deficiency anemia. The aim of this study was to investigate the association of Helicobacter pylori infection with serum iron and ferritin levels.Methods : In this study, the serum of ۱۸۰ patients referred to a medical diagnostic laboratory with clinical symptoms was collected. Then the IgG antibody titer of Helicobacter pylori and the levels of ferritin and iron in the serum were examined. The results were analyzed using statistical test and SPSS software.Results : Of the ۱۸۰ samples performed, ۴۵ samples (۲۵%) were positive for Helicobacter pylori titer IgG. ۱۷ (۳۷%) of IgG-positive people had low serum iron levels and ۱۱ samples (۲۴.۴%) of IgG-positive had serum ferritin deficiency. In the group of people with a negative IgG antibody titer, ۴۳ (۳۱.۸%) had serum iron deficiency and ۴۷ samples (۳۴.۸%) had low serum ferritin levels. There were no significant correlation between ferritin levels, serum iron, and IgG titer of Helicobacter pylori by using chi-square test (p = ۱.۴۳).Conclusion : According to the results presented in this paper, which points to the high prevalence of iron deficiency anemia, further studies are needed. Also, in order to reduce the prevalence of Helicobacter pylori infection due to the high percentage of positive IgG antibody titer of Helicobacter pylori infection, it is necessary to use codified educational and health programs to reduce the prevalence of this bacteria.