Cytotoxicity of Hemiscorpius lepturus scorpion venom on breast cancer

Background and Aim : Breast cancer is one of the most related cancer deaths among women. The scorpion venom consists of various peptides and proteins with cytotoxic, apoptotic and growth inhibitory effects on various cancers. Studying the Cytotoxic effect Hemiscorpius lepturus scorpion venom on T۴۷D breast cancer cell line was the main aim of the current study.Methods : The T۴۷D cells were cultured as monolayer in RPMI۱۶۴۰ medium. The toxicity of the scorpion venom on T۴۷D cell line was evaluated by MTT assay and the IC۵۰ was calculated. The HEK۲۹۳ cell line was used as control cell line.Results : The MTT assay results showed the time and dose-dependent inhibitory effect of H. lepturus venom on T۴۷D cell line. However, such effect was not observed on HEK۲۹۳ cell line in identical dose.Conclusion : The achieved results indicate the anticancer effect of H. lepturus venom on T۴۷D breast cancer cell line.

کلیدواژه ها:

Hemiscorpius lepturus ، Breast cancer ، T۴۷D ، Cytotoxic effect