EMERGENCE OF VANCOMYCIN-RESISTANT COAGULASE-NEGATIVE STAPHYLOCOCCI IN AN EDUCATIONAL AND THERAPEUTIC HOSPITAL OF SARAB IRAN

Background and Aim : Coagulase-negative staphylococci (CoNS) are major opportunistic pathogens causing nosocomial infections due to use of medical devices and implants. Today, increasing prevalence of antibiotic resistant, especially vancomycin resistant CoNS is a warning problem and can lead to failure in treatment. The aim of this study was to determine the prevalence of Vancomycin-resistant clinical isolates of coagulase-negative staphylococci at Imam Khomeini Educational and Treatment Center of SarabMethods : The clinical specimens (blood, urine, wound) were collected from patients included ۲۸۵ )۶۲%( females and ۱۷۵ (۳۸%) males during the study. The strains were isolated by routine culture techniques and microbiological methods. The antibiotic resistance pattern of the isolates was detected by disk diffusion method and susceptibility testing to vancomycin was performed by E-test method according to Clinical and Laboratory Standards Institute guidelinesResults : Out of ۴۶۰ clinical samples, ۸۲% of isolates were identified as Staphylococcus epidermidis. Also ۱۸% of isolates were Staphylococcus saprophyticus. Among the S.epidermidis isolates, ۸۱% and ۱۹% of them were resistant to Co-trimoxazole and Vancomycin, while ۵۳% and ۶% of S. saprophyticus isolates were resistant to Co-trimoxazole and Vancomycin, respectivelyConclusion : Significant increase in the prevalence and emergence of Vancomysin-resistant coagulase-negative Staphylococci is a concerning public health problem. Therefore, determining the antimicrobial susceptibility profile of CoNS strains is necessary before the treatment.

کلیدواژه ها:

Staphylococci ، Coagulase-negative ، Vancomycin ، Resistance