Inhibitory effect of Nardostachys jatamansi plain aqueous and alcoholic extract of fungus Malassezia

Background and Aim : The opportunistic yeasts of the Malassezia genus are naturally inhabited by human beings and warm-blooded animals. These yeasts, under certain conditions, can produce diseases such as tinea versicolor, seborrheic dermatitis and even systemic infections. In recent decades' opportunistic fungal infections caused by Malassezia species such as Malassezia fur fur, which is caused by the significant increase in the incidence of disease Nardostachys jatamansi plant has numerous health benefits.Methods : In this study, aqueous, ethanol and methanol extracts of Nardostachys jatamansi using on the fungus Malassezia, in disk and plate method, in the well method, a minimum growth inhibitory concentration (MIC) and minimum fungicide concentration (MFC) was studied.Results : In the disc method, the lowest diameter of the aqueous extract in ۱۰ μl was ۷.۳۳± ۰.۳۳ mm and the largest diameter was methanol extract with a length of ۱۴.۶۶±۰.۳۳ mm at a concentration of ۵۰ μl. In the well method, the lowest diameter was ethanolic extract at a concentration of ۸۰ μl with a diameter of ۱۵ ± ۰۰ mm and the largest diameter was aqueous extract with a length of ۲۲.۳۳±۰.۳۱ mm at a concentration of ۱۱۰ μl.Conclusion : The results of this study showed that ethanolic, methanolic and aqueous extracts of the Nardostachys jatamansi plant had an antifungal effect on Malaysia in laboratory conditions. According to these results, in the future, more research should be done on this plant in vitro and in vivo conditions and its antimicrobial compounds should be identified and extracted. Due to the fact that herbal medicines have fewer side effects, to reduce the side effects and drug resistance caused by chemical drugs, it is hoped that the effective compounds of this plant can be used in the future to treat fungal diseases as a suitable alternative to chemical drugs.

کلیدواژه ها:

Nardostachys jatamansi ، Malassezia ، anti-fungal effect