Physicochemical inactivation of SARS-CoV ۲ versus SARS and MERS

Background and Aim : SARS-CoV-۲ could be spreading via respiratory droplets or through direct and indirect contact with incubation times between ۲h-۱۴ days. In the present study, we reviewed all available information about the susceptibility and persistence of SARS-CoV ۲.Methods : The entire related studies were collected and analyzed according to keywords including persistence on inanimate and animate surfaces, virucidal compounds and physical treatments from valid databases.Results : In comparison to the SARS- CoV and MERS-CoV, SARS-CoV۲ can remain infective only ۳۰ min to ۲h on different types of materials dependent on the other physical conditions. Notably, it is much more sensitive than SARS-CoV and MERS-CoV to the heat treatment and is completely inactivated in less than ۵ min at ۷۰°C. Contrary to expectations, coronaviruses have shown resistance to a wide range of disinfectants. Hydrogen peroxide ۰.۵ %, sodium hypochlorite ۰.۵% and alcohol-based solutions have scored higher disinfection activity due to their effectiveness in less than ۱ min contact time, easy access and reasonable price.Conclusion : The existence of different variants of this strain can differentiate it from SARS-CoV and MERS-CoV. The mutations in the spike protein of SARS-CoV ۲ can increase its multiplication and transmission up to ۳ to ۹ times. The susceptibility assessment of its different variants to physical and chemical treatments can aid in developing new disinfection formulations and efficient control of the transmission and spread of this virus.

کلیدواژه ها:

SARS-CoV-۲ ، Persistence on inanimate surface ، Physical treatment ، Chemical inactivation ، Disinfection