Identification of nano-lipid system containing curcumin extract in order to prevent tooth decay by Mozaffari method

Background and Aim : The aim of this study was to characterize the nano-lipid system containing curcumin extract in order to prevent tooth decay. For this purpose, a lipid system containing curcumin extract has been developed for optimal anti-streptococcus mutans by Muzaffari method.Methods : The aim of this study was to characterize the nano-lipid system containing curcumin extract in order to prevent tooth decay. For this purpose, a lipid system containing curcumin extract has been developed for optimal anti-streptococcus mutans by Muzaffari method.Results : The average particle diameter was about ۶۰ nm and its zeta potential was -۱۶ mV. The loading rate in nanoparticles was ۹۱%, which was calculated by reading the absorption of light from the standard curcumin curve. In addition, minimum inhibitory concentration (MIC) of nanoparticles against Streptococcus mutans, was ۰.۲۰۴ and ۰.۴۳۸ mg/mL for starch nanoparticles and pure curcumin, respectively. It was also found that starch nanoparticles had inhibitory effect on bacterial biofilm.Conclusion : nano-particles improve adhesion properties and interactions with enamel and prevent dental caries of Streptococcus mutans.

کلیدواژه ها:

Streptococcus mutans ، Curcumin ، Dental caries