Antibacterial and antifungal activity of Onosma essential oils compared to four common antibioticsMON ANTIBIOTICS

Background and Aim : Essential oils are recommended to treat infectious diseases, but data about their efficacy in scientific literature are insignificant. Antibacterial and antifungal activity of the essential oils from Onosma microcarpum and Onosma chlorotricum against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans and Candida glaberata evaluatedMethods : Plants were collected in September ۲۰۱۵ from the suburb of Koohdasht, Lorestan province. Essential oil extracted by hydro distillation method, the antimicrobial effects of these essential oils was determined by disc diffusion method and microdilution method. Results were compared with the Vancomycin, Amikacin, Fluconazole and Nystatin by SPSS software.Results : The results showed that both essential oils possess antimicrobial activity against all tested microbes, however essential oil of O.chlorotricum has antimicrobial activity stronger than O.microcarpum. the mean inhibitory diameter of growth (mm) of S.aureus (۲۴±۱.۲), E.coli (۲۲.۵± ۰/۶) P.aeruginosa (۲۰.۵±۰.۱۶) in the presence of O.chlorotricum essential oil was higher than O.microcarpum. Also O.chlorotricum showed more antifungal activity with ۲۱ and ۱۹.۳ mean of inhibition zones (mm) for C.albicans and C.glaberata respectively. The MIC assay of the O.chlorotricum essential oil showed antibacterial and antifungal activity stronger than O. microcarpum, The lowest MIC for S.aureus and C.albicans was ۳۲.۰۳ and ۶۴.۰۶ ?g/ml respectively. The highest MIC for P.aeruginosa and C.glaberata was ۱۲۸.۱۲ ۵۱۲.۵ ?g/ml respectively. essential oils often, have a more antibacterial and antifungal activity rather than tested antibiotics.Conclusion : The obtained results suggest that, O.chlorotricum and O.microcarpum essential oils are potentially a good source of antimicrobial agents which can be used for supporting primary health care and alternative treatment of common antibiotics.

کلیدواژه ها:

Essential Oil ، Antibacterial ، Antifungal ، Onosma ، Antibiotics