Bacteriophages and their role in the treatment of common bacterial infections

Background and Aim : Bacterial infections are one of the most common types of infections that occur in many people of all ages. And in many cases, they can be fatal. Apart from that, they cause a lot of damage to the healthcare system and the economy of any country. Today, antibiotic resistance or drug interactions cause bacterial infections in some cases to have more destructive effects. Therefore, new therapeutic approaches can be an effective way to fight bacterial infections and minimize mortality and reduce the economic costs of treatment and hospitalization. Bacteriophage therapy is one of these approaches. Bacteriophages are viruses that attack bacteria and are specific to bacteria and can kill them. These viruses cannot attack eukaryotes due to their specificity and therefore can be considered as one. Modern methods of treatment should be considered. Therefore, this study aimed to investigate the characteristics of bacteriophages and their role in the treatment of common bacterial infections.Methods : Articles related to the subject were searched on two websites, Pubmed, science direct, and systematic review articles that examined the effects of bacteriophages on the prevention and reduction of common bacterial infections.Results : The results of various studies indicate the role of lytic bacteriophages in eliminating or reducing bacterial infections. Animal studies also seem to confirm the effective role of bacteriophages in reducing bacterial infections. The positive effects and reduction of bacterial infection in strains containing antibiotic resistance are seen after the use of bacteriophages.Conclusion : The results of studies show that to reduce bacterial infections, especially antibiotic-resistant strains, the use of bacteriophages can play an effective role, which is confirmed in both invitro and invivo conditions, and it is hoped that with the right perspective, approach The use of bacteriophages has been instrumental in both reducing mortality and improving economic conditions in communities.

کلیدواژه ها:

Bacterial infections ، Bacteriophage ، Bacteria