Genotypes of New Delhi Metallo-beta-lactamase-Producing Escherichia coli among Clinical Isolates around the World: The First Review

Background and Aim : New Delhi Metallo-beta-lactamase (NDM)-producing Escherichia coli (E. coli) is allegedly perceived as one of the most indispensable multidrug-resistant bacteria causing infections in hospitals and clinic domains. The nobility of the present study was evaluation of epidemiology, genotypes and the most prevalent sequence types (STs) of NDM-producing E. coli among clinical isolates worldwide.Methods : Several international databases including Medline, Embase, and Web of sciences were searched from March ۲۰۱۸ to June ۲۰۱۸ to discern studies addressed the prevalence of NDM-producing E. coli around the worldResults : Of the ۹۷۴ records identified from the databases, ۱۱۰ studies fulfilled the eligibility criteria ostensibly. The analyses manifested that the prevalence of NDM-producing E. coli were ۸۲.۶%, ۱۲.۹%, ۱.۴%, ۰.۹% and ۱.۹% in Asia, Europe, America, Africa and Oceania continents, respectively. According to our results, the most common reported STs among NDM- producing E. coli were ST۱۰۱, ST۱۶۷, ST۱۳۱, ST۴۰۵, ST۴۱۰ and ST۶۴۸.Conclusion : The dissemination of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups such as ST۱۰۱ and ST۱۶۷ are one of the main causes of E. coli infection in different countries. Then the control of the spread of NDM variants-producing E. coli especially in the most common E.coli clonal groups, is very important to prevent the spread of antimicrobial resistance around the world.

کلیدواژه ها:

New Delhi Metallo-beta-Lactamase ، E. coli ، Sequence Type