Endometrial and follicular development following stair-step and traditional protocols in women with polycystic ovary syndrome: An RCT

Background: Various strategies have been proposed for polycystic ovary syndrome (PCOS) treatment. Objective: To investigate and compare the number and size of ovarian follicles, endometrial thickness, and ovulation rate by traditional protocol (TP) and stair-step protocol (SSP). Materials and Methods: Sixty infertile PCOS women were allocated into two groups (SSP = ۳۰ and control TP = ۳۰) between May and October ۲۰۱۹ in the Besat Hospital, Sanandaj, Iran. In the SSP group, the infertile women were treated with ۵۰ mg/daily clomiphene citrate (CC) for five days, while the nonresponsive women were prescribed ۱۰۰ mg daily CC for five days in the same cycle. The maximum dose (۱۵۰ mg) was administered until ovulation occurred. In the control group, in non-ovulatory cases, the dose was increased in the next cycle. Ultrasound was used to detect ovulation. Results: Endometrial thickness changes with various doses of CC were significantly different in the TP. The comparison of both protocols showed a significant difference in endometrial thickness only at ۵۰ mg CC. The number of follicles in the left ovary was significantly different in both protocols at ۱۵۰-mg CC. The size of ovarian follicles in the left ovary was significantly different between the two protocols at ۱۰۰-mg CC. The ovulation rate was significantly different in the SSP at ۱۰۰- and ۱۵۰-mg doses of CC. Moreover, ۸۶% of ovulation occurred at ۱۰۰-mg CC in the SSP, while this rate was ۷۳% in the TP. Conclusion: The most appropriate dose for ovulation in patients with PCOS is ۱۰۰ mg CC.  

کلیدواژه ها:

Polycystic ovary syndrome ، Clomiphene ، Infertility ، Ovulation induction. ، سندرم تخمدان پلی کیستیک ، کلومیفن سیترات ، پروتکل پلکانی ، پروتکل سنتی.